5-{[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

A synthetic small molecule featuring a thiadiazole core with sulfonamide and arylsulfonamide substituents. It is an experimental compound that acts as a potent inhibitor of carbonic anhydrase 2 (CA2), with reported nanomolar affinity (Ki = 0.3 nM). Carbonic anhydrase inhibitors are used in the treatment of conditions such as glaucoma, epilepsy, and altitude sickness; however, this specific compound is not approved for clinical use and has no known marketed indications or brand names. Its primary activity is inhibition of the enzyme carbonic anhydrase 2[6][8].

Other names

5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide